Article
Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.
Human molecular genetics - 15 Jun 2015
Mikhail Fadi, Calingasan Noel, Parolari Luca, Subramanian Aarthi, Yang Lichuan, Flint Beal M
Abstract excerpt
LRRK2 (leucine-rich repeat kinase) mutations constitute the most common cause of familial Parkinson's disease (PD). Microtubule-associated protein tau mutations cause a group of neurodegenerative diseases termed tauopathies. Genome-wide association studies show that, after α-synuclein, polymorphisms in the tau gene have the second strongest genetic association with PD. In a proportion of PD patients with LRRK2...
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