Article
Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation.
PloS one - 1 Jan 2015
Mugumbate Grace, Abrahams Katherine A, Cox Jonathan A G, Papadatos George, van Westen Gerard, Lelièvre Joël, Calus Szymon T, Loman Nicholas J, Ballell Lluis, Barros David, Overington John P, Besra Gurdyal S
Abstract excerpt
The lack of success in target-based screening approaches to the discovery of antibacterial agents has led to reemergence of phenotypic screening as a successful approach of identifying bioactive, antibacterial compounds. A challenge though with this route is then to identify the molecular target(s) and mechanism of action of the hits. This target identification, or deorphanization step, is often essential in...
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