Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distributed abnormalities of brain white matter architecture in patients with dominant optic atrophy and OPA1 mutations.

Journal of neurology - 1 May 2015

Rocca Maria A, Bianchi-Marzoli Stefania, Messina Roberta, Cascavilla Maria Lucia, Zeviani Massimo, Lamperti Costanza, Milesi Jacopo, Carta Arturo, Cammarata Gabriella, Leocani Letizia, Lamantea Eleonora, Bandello Francesco, Comi Giancarlo, Falini Andrea, Filippi Massimo

Abstract excerpt

Using advanced MRI techniques, we investigated the presence and topographical distribution of brain grey matter (GM) and white matter (WM) alterations in dominant optic atrophy (DOA) patients with genetically proven OPA1 mutation as well as their correlation with clinical and neuro-ophthalmologic findings. Nineteen DOA patients underwent neurological, neuro-ophthalmologic and brainstem auditory evoked potentials...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anisotropy
Share to Diffusion Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electroencephalography

Share to Evoked Potentials, Auditory

Share to Neurologic Examination

Share to Optic Atrophy, Autosomal Dominant

Share to Statistics, Nonparametric

Share to White Matter

Source

Identifiers

PMID: 25794858
DOI: 10.1007/s00415-015-7696-5

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distributed abnormalities of brain white matter architecture in patients with dominant optic atrophy and OPA1 mutations.PMID 25794858Read ↗

Dominant optic atrophySemantic proximity Read ↗

Dominant optic atrophy: updates on the pathophysiology and clinical manifestations of the optic atrophy 1 mutation.Semantic proximity Read ↗

Imaging of the macula indicates early completion of structural deficit in autosomal-dominant optic atrophy.Semantic proximity Read ↗

OPA1 Dominant Optic Atrophy: Pathogenesis and Therapeutic Targets.Semantic proximity Read ↗

Rhesus macaques with an OPA1 mutation demonstrate features of autosomal dominant optic atrophy.Semantic proximity Read ↗

Early macular retinal ganglion cell loss in dominant optic atrophy: genotype-phenotype correlation.Semantic proximity Read ↗

Dominant optic atrophy, neuropathy, ataxia, white matter FLAIR hypersignals, middle cerebellar peduncule atrophy and asthenia in OPA1 mutation.Semantic proximity Read ↗

Reduction of inner retinal thickness in patients with autosomal dominant optic atrophy associated with OPA1 mutations.Semantic proximity Read ↗

Genotype-phenotype heterogeneity of ganglion cell and inner plexiform layer deficit in autosomal-dominant optic atrophy.Semantic proximity Read ↗

Thickness mapping of individual retinal layers and sectors by Spectralis SD-OCT in Autosomal Dominant Optic Atrophy.Semantic proximity Read ↗

Pattern of retinal ganglion cell loss in dominant optic atrophy due to OPA1 mutations.Semantic proximity Read ↗

Multiple sclerosis-like disorder in OPA1-related autosomal dominant optic atrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.