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Article

Identification of genetic loci affecting the severity of symptoms of Hirschsprung disease in rats carrying Ednrbsl mutations by quantitative trait locus analysis.

PloS one - 1 Jan 2015

Huang Jieping, Dang Ruihua, Torigoe Daisuke, Lei Chuzhao, Lan Xianyong, Chen Hong, Sasaki Nobuya, Wang Jinxi, Agui Takashi

Abstract excerpt

Hirschsprung's disease (HSCR) is a congenital disease in neonates characterized by the absence of the enteric ganglia in a variable length of the distal colon. This disease results from multiple genetic interactions that modulate the ability of enteric neural crest cells to populate developing gut. We previously reported that three rat strains with different backgrounds (susceptible AGH-Ednrbsl/sl, resistant...

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Share to Chromosomes, Mammalian
Share to Gastrointestinal Tract

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hirschsprung Disease

Share to Hybridization, Genetic

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Receptor, Endothelin B

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Identifiers

PMID: 25790447
DOI: 10.1371/journal.pone.0122068
PMCID: PMC4366197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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