Article
Genetic background strongly modifies the severity of symptoms of Hirschsprung disease, but not hearing loss in rats carrying Ednrb(sl) mutations.
PloS one - 1 Jan 2011
Dang Ruihua, Torigoe Daisuke, Suzuki Sari, Kikkawa Yoshiaki, Moritoh Kanako, Sasaki Nobuya, Agui Takashi
Abstract excerpt
Hirschsprung disease (HSCR) is thought to result as a consequence of multiple gene interactions that modulate the ability of enteric neural crest cells to populate the developing gut. However, it remains unknown whether the single complete deletion of important HSCR-associated genes is sufficient to result in HSCR disease. In this study, we found that the null mutation of the Ednrb gene, thought indispensable for...
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