Article
The -844 G>A PAI-1 polymorphism is associated with acute coronary syndrome in Mexican population.
Disease markers - 1 Jan 2015
García-González Ilian Janet, Valle Yeminia, Sandoval-Pinto Elena, Valdés-Alvarado Emmanuel, Valdez-Haro Angélica, Muñoz-Valle José Francisco, Flores-Salinas Héctor Enrique, Figuera-Villanueva Luis Eduardo, Dávalos-Rodríguez Nory Omayra, Padilla-Gutiérrez Jorge Ramón
Abstract excerpt
BACKGROUND: Acute coronary syndrome (ACS) has an important impact in public health with high morbidity and mortality. Prothrombotic and proinflammatory states are involved in the pathogenesis of the disease. Plasminogen activator inhibitor-1 (PAI-1) is the major inhibitor of the fibrinolysis and also is part of immune response. The -844 G>A gene polymorphism is related to increased PAI-1 protein levels. The aim...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.