<scp>SLIT</scp>2/<scp>ROBO</scp>1‐miR‐218‐1‐<scp>RET</scp>/<scp>PLAG</scp>1: a new disease pathway involved in <scp>H</scp>irschsprung's disease

Abstract excerpt

Hirschsprung's disease (HSCR) is a rare congenital disease caused by impaired proliferation and migration of neural crest cells. We investigated changes in expression of microRNAs (miRNAs) and the genes they regulate in tissues of patients with HSCR. Quantitative real-time PCR and immunoblot analyses were used to measure levels of miRNA, mRNAs, and proteins in colon tissues from 69 patients with HSCR and 49...

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