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Article

Genetic analysis of the CDI pathway from Burkholderia pseudomallei 1026b.

PloS one - 1 Jan 2015

Koskiniemi Sanna, Garza-Sánchez Fernando, Edman Natasha, Chaudhuri Swarnava, Poole Stephen J, Manoil Colin, Hayes Christopher S, Low David A

Abstract excerpt

Contact-dependent growth inhibition (CDI) is a mode of inter-bacterial competition mediated by the CdiB/CdiA family of two-partner secretion systems. CdiA binds to receptors on susceptible target bacteria, then delivers a toxin domain derived from its C-terminus. Studies with Escherichia coli suggest the existence of multiple CDI growth-inhibition pathways, whereby different systems exploit distinct target-cell...

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Identifiers

PMID: 25786241
DOI: 10.1371/journal.pone.0120265
PMCID: PMC4364669

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