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Abrupt Loss of MLH1 and PMS2 Expression in Endometrial Carcinoma

18 Mar 2015

Abstract excerpt

Given that endometrial cancer (EC) is often the sentinel cancer for female Lynch syndrome patients, we have successfully implemented universal screening of ECs and have previously shown that this is the preferred method to identify these patients. However, during the course of universal screening of EC, we encountered 6 cases with an unusual pattern of mismatch-repair protein immunohistochemistry that has not...

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PMID: 25786082
DOI: 10.1097/pas.0000000000000415

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