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Article

Prevalence of HCV NS3 pre-treatment resistance associated amino acid variants within a Scottish cohort.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Apr 2015

Shepherd Samantha J, Abdelrahman Tamer, MacLean Alasdair R, Thomson Emma C, Aitken Celia, Gunson Rory N

Abstract excerpt

BACKGROUND: Protease inhibitors (PI) including boceprevir, telaprevir and simeprevir have revolutionised HCV genotype 1 treatment since their introduction. A number of pre-treatment resistance associated amino acid variants (RAVs) and polymorphisms have been associated with reduced response to treatment. OBJECTIVES: We measured the prevalence of RAVs/polymorphisms in a PI treatment-naïve HCV genotype 1 Scottish...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25766988
DOI: 10.1016/j.jcv.2015.02.005
PMCID: PMC4728298

Genes

NHS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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