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Article

[The C5 gene polymorphism in patients with PNH].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Feb 2015

Nishimura Jun-Ichi, Kanakura Yuzuru

Abstract excerpt

This review is a commentary on an article entitled "Genetic variants in C5 and poor response to eculizumab" (N Engl J Med. 2014; 370: 632-639). The molecular basis for the poor response to eculizumab in Japanese patients is unclear. Of 345 Japanese patients with paroxysmal nocturnal hemoglobinuria (PNH) who received eculizumab, 11 showed a poor response. All 11 had a single missense C5 heterozygous mutation,...

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Share to Polymorphism, Genetic
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Source

Identifiers

PMID: 25765788
DOI: 10.11406/rinketsu.56.103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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