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Article

Examining the feasibility of clinical grade CD271+ enrichment of mesenchymal stromal cells for bone regeneration.

PloS one - 1 Jan 2015

Cuthbert Richard J, Giannoudis Peter V, Wang Xiao N, Nicholson Lindsay, Pawson David, Lubenko Anatole, Tan Hiang B, Dickinson Anne, McGonagle Dennis, Jones Elena

Abstract excerpt

INTRODUCTION: Current clinical trials utilize mesenchymal stromal cells (MSCs) expanded in culture, however these interventions carry considerable costs and concerns pertaining to culture-induced losses of potency. This study assessed the feasibility of new clinical-grade technology to obtain uncultured MSC isolates from three human intra-osseous tissue sources based on immunomagnetic selection for CD271-positive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25760857
DOI: 10.1371/journal.pone.0117855
PMCID: PMC4356586

Genes

MSC
CXCL12
SPARC
SUSD2
VEGFC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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