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Article

Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer.

Oncotarget - 20 Mar 2015

Tsigelny Igor F, Wheler Jennifer J, Greenberg Jerry P, Kouznetsova Valentina L, Stewart David J, Bazhenova Lyudmila, Kurzrock Razelle

Abstract excerpt

We hypothesized that aberrations activating epidermal growth factor receptor (EGFR) via dimerization would be more sensitive to anti-dimerization agents (e.g., cetuximab). EGFR exon 19 abnormalities (L747_A750del; deletes amino acids LREA) respond to reversible EGFR kinase inhibitors (TKIs). Exon 20 in-frame insertions and/or duplications (codons 767 to 774) and T790M mutations are clinically resistant to...

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Identifiers

PMID: 25760241
DOI: 10.18632/oncotarget.3472
PMCID: PMC4467419

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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