Article
EGFR exon 19 insertion EGFR-K745_E746insIPVAIK and others with rare XPVAIK amino-acid insertions: Preclinical and clinical characterization of the favorable therapeutic window to all classes of approved EGFR kinase inhibitors.
Lung cancer (Amsterdam, Netherlands) - 1 Jul 2023
Shaffer William, Kobayashi Ikei S, Sentana-Lledo Daniel, Sundararaman Shriram, Lee Meghan D, Rangachari Deepa, VanderLaan Paul A, Kobayashi Susumu S, Costa Daniel B
Abstract excerpt
BACKGROUND: The epidermal growth factor receptor (EGFR)-K745_E746insIPVAIK and others with XPVAIK amino-acid insertions are exon 19 insertion mutations, which, at the structural modeling level, resemble EGFR tyrosine kinase inhibitor (TKI)-sensitizing mutants. An important unmet need is the characterization of therapeutic windows plus clinical outcomes of exon 19 XPVAIK amino-acid insertion mutations to available...
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