Article
A novel clonal t(1;4)(p36.1;q31) translocation in acute promyelocytic leukaemia.
Journal of clinical pathology - 1 May 2015
Zhang Xueya, Pan Jingxin
Abstract excerpt
The majority of patients with acute promyelocytic leukaemia (APL) carry the hallmark t(15;17)(q22;q21) translocation, involving the promyelocytic leukaemia/retinoic acid receptor-α (PML/RARα) fusion gene, and by sensitivity of blast cells to all-trans retinoic acid (ATRA) and/or arsenic trioxide therapy. The incidence and prognostic significance of additional chromosomal abnormalities in APL are still obscure. We...
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