Article
The capability of Pseudomonas aeruginosa to recruit zinc under conditions of limited metal availability is affected by inactivation of the ZnuABC transporter.
Metallomics : integrated biometal science - 1 Jun 2015
D'Orazio Melania, Mastropasqua Maria Chiara, Cerasi Mauro, Pacello Francesca, Consalvo Ada, Chirullo Barbara, Mortensen Brittany, Skaar Eric P, Ciavardelli Domenico, Pasquali Paolo, Battistoni Andrea
Abstract excerpt
The ability of a large number of bacterial pathogens to multiply in the infected host and cause disease is dependent on their ability to express high affinity zinc importers. In many bacteria, ZnuABC, a transporter of the ABC family, plays a central role in the process of zinc uptake in zinc poor environments, including the tissues of the infected host. To initiate an investigation into the relevance of the zinc...
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