Article
Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa drives clinically relevant phenotypes and infection outcomes.
Infection and immunity - 10 Feb 2026
Bosc Lola, Sécher Thomas, Ball Geneviève, Le Pennec Deborah, Tribout Mathilde, Ba Moly, Bai Yingjie, Ouerdane Laurent, Arnoux Pascal, Denis Yann, Lei Xiaoguang, Bordi Christophe, Heuzé-Vourc'h Nathalie, Häussler Susanne, Gomez Nicolas Oswaldo, Voulhoux Romé
Abstract excerpt
Biological metals are vital trace elements required by metalloproteins, which are involved in virtually every cellular, structural, and catalytic function of the bacterial cell. Bacterial pathogenesis involves a tug-of-war between the host's nutritional immunity sequestering essential metals and the invading pathogens that deploy adapted high-metal affinity uptake strategies, such as metallophores, in order to...
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