Article
Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia.
Circulation journal : official journal of the Japanese Circulation Society - 1 Jan 2015
Sugihara Shinobu, Hisatome Ichiro, Kuwabara Masanari, Niwa Koichiro, Maharani Nani, Kato Masahiko, Ogino Kazuhide, Hamada Toshihiro, Ninomiya Haruaki, Higashi Yukihito, Ichida Kimiyoshi, Yamamoto Kazuhiro
Abstract excerpt
BACKGROUND: Uric acid (UA) serves as an antioxidant in vascular endothelial cells. UA transporter 1 (URAT1) encoded by SLC22A12 is expressed in the kidney and vessels and its loss of function causes hypouricemia. The purpose of this study was to examine whether there is any endothelial dysfunction in patients with hypouricemia. METHODS AND RESULTS: Twenty-six patients with hypouricemia (<2.5 mg/dl) and 13 healthy...
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