Article
Autophagy is involved in high glucose-induced heart tube malformation.
Cell cycle (Georgetown, Tex.) - 1 Jan 2015
Wang Guang, Huang Wen-qing, Cui Shu-dan, Li Shuai, Wang Xiao-yu, Li Yan, Chuai Manli, Cao Liu, Li Jiang-chao, Lu Da-xiang, Yang Xuesong
Abstract excerpt
Both pre-gestational and gestational diabetes have an adverse impact on heart development, but little is known about the influence on the early stage of heart tube formation. Using early gastrulating chick embryos, we investigated the influence of high glucose on the process of heart tube formation, specifically during the primary heart field phase. We demonstrated that high-glucose exposure resulted in 3 types...
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