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Article

In silico analysis of RET variants in medullary thyroid cancer: from the computer to the bedside.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Apr 2015

Heineman Thomas E, Joshi Rohan, Cohen Marc A, Kuhel William I, Kutler David I

Abstract excerpt

OBJECTIVE: The American Thyroid Association (ATA) medullary thyroid cancer (MTC) guidelines group RET variants, in the setting of familial medullary thyroid cancer and multiple endocrine neoplasia type 2, into 4 classes of severity based on epidemiological data. The aim of this study was to determine if genotype correlates with phenotype in RET missense mutations. STUDY DESIGN: In silico mutational tolerance...

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Share to Carcinoma, Medullary
Share to Carcinoma, Neuroendocrine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Multiple Endocrine Neoplasia Type 2a

Share to Mutation, Missense

Share to Proto-Oncogene Proteins c-ret

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Share to Thyroid Neoplasms

Source

Identifiers

PMID: 25733075
DOI: 10.1177/0194599815569709

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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