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Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs

26 Feb 2015

Abstract excerpt

Defects in articular cartilage ultimately result in loss of joint function. Repairing cartilage defects requires cell sources. We developed an approach to generate scaffoldless hyaline cartilage from human induced pluripotent stem cells (hiPSCs). We initially generated an hiPSC line that specifically expressed GFP in cartilage when teratoma was formed. We optimized the culture conditions and found BMP2,...

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PMID: 25733017
DOI: 10.1016/j.stemcr.2015.01.016

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