Article
F344/NTac Rats Chronically Exposed to Bromodichloroacetic Acid Develop Mammary Adenocarcinomas With Mixed Luminal/Basal Phenotype and Tgfβ Dysregulation.
Veterinary pathology - 1 Jan 2016
Harvey J B, Hong H-H L, Bhusari S, Ton T-V, Wang Y, Foley J F, Peddada S D, Hooth M, DeVito M, Nyska A, Pandiri A R, Hoenerhoff M J
Abstract excerpt
Breast cancer is the most common cancer and the second-leading cause of cancer mortality in women in the United States. A recent 2-year National Toxicology Program carcinogenicity study showed an increased incidence of proliferative mammary lesions (hyperplasia, fibroadenoma, adenocarcinoma) in F344/NTac rats exposed to bromodichloroacetic acid (BDCA), a disinfection by-product in finished drinking water with...
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