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Article

ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis

17 Feb 2015

Abstract excerpt

Increases in circulating glucagon during fasting maintain glucose balance by stimulating hepatic gluconeogenesis. Acute ethanol intoxication promotes fasting hypoglycemia through an increase in hepatic NADH, which inhibits hepatic gluconeogenesis by reducing the conversion of lactate to pyruvate. Here we show that acute ethanol exposure also lowers fasting blood glucose concentrations by inhibiting the...

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PMID: 25730876
DOI: 10.1073/pnas.1424641112

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