Article
Quantitative proteomics analysis of the Arg/N-end rule pathway of targeted degradation in Arabidopsis roots.
Proteomics - 1 Jul 2015
Zhang Hongtao, Deery Michael J, Gannon Lucy, Powers Stephen J, Lilley Kathryn S, Theodoulou Frederica L
Abstract excerpt
According to the Arg/N-end rule pathway, proteins with basic N-termini are targeted for degradation by the Arabidopsis thaliana E3 ligase, PROTEOLYSIS6 (PRT6). Proteins can also become PRT6 substrates following post-translational arginylation by arginyltransferases ATE1 and 2. Here, we undertook a quantitative proteomics study of Arg/N-end rule mutants, ate1/2 and prt6, to investigate the impact of this pathway...
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