Article
BIG enhances Arg/N-degron pathway-mediated protein degradation to regulate Arabidopsis hypoxia responses and suberin deposition.
The Plant cell - 3 Sept 2024
Zhang Hongtao, Rundle Chelsea, Winter Nikola, Miricescu Alexandra, Mooney Brian C, Bachmair Andreas, Graciet Emmanuelle, Theodoulou Frederica L
Abstract excerpt
BIG/DARK OVEREXPRESSION OF CAB1/TRANSPORT INHIBITOR RESPONSE3 is a 0.5 MDa protein associated with multiple functions in Arabidopsis (Arabidopsis thaliana) signaling and development. However, the biochemical functions of BIG are unknown. We investigated a role for BIG in the Arg/N-degron pathways, in which substrate protein fate is influenced by the N-terminal residue. We crossed a big loss-of-function allele to...
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