Article
Somatic thrombopoietin (THPO) gene mutations in childhood myeloid leukemias.
International journal of hematology - 1 Jul 2015
Houwing Maite E, Koopman-Coenen Eva A, Kersseboom Rogier, Gooskens Saskia, Appel Inge M, Arentsen-Peters Susan T C J M, de Vries Andrica C H, Reinhardt Dirk, Stary Jan, Baruchel André, de Haas Valerie, Blink Marjolein, Lopes Cardozo Rob H, Pieters Rob, Michel Zwaan C, van den Heuvel-Eibrink Marry M
Abstract excerpt
We report, for the first time, a non-syndromic infant with a reversible myeloproliferative disease that harbors a germline hereditary thrombopoietin (THPO) gene mutation, a condition that is known to induce familial thrombocytosis at increasing age. In order to investigate whether somatic THPO gene mutations play a role in sporadic pediatric myeloproliferative diseases, we performed a mutation screening of a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.