Article
Identification and characterization of two novel germline RET variants associated with medullary thyroid carcinoma.
Endocrine - 1 Jun 2015
Silva A L, Carmo F, Moura M M, Domingues R, Espadinha C, Leite V, Cavaco B, Bugalho M J
Abstract excerpt
Activating germline mutations in the RET proto-oncogene are responsible for about 98 % of the familial forms of medullary thyroid carcinoma (MTC), which represent 25 % of all MTC cases. The search for germline mutations in this gene is important for the recognition of hereditary forms of MTC and further identification of at-risk relatives who may benefit from early clinical intervention. Genotype-phenotype...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.