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Rifampicin reduces advanced glycation end products and activates DAF-16 to increase lifespan in Caenorhabditis elegans.

Aging cell - 1 Jun 2015

Golegaonkar Sandeep, Tabrez Syed S, Pandit Awadhesh, Sethurathinam Shalini, Jagadeeshaprasad Mashanipalya G, Bansode Sneha, Sampathkumar Srinivasa-Gopalan, Kulkarni Mahesh J, Mukhopadhyay Arnab

Abstract excerpt

Advanced glycation end products (AGEs) are formed when glucose reacts nonenzymatically with proteins; these modifications are implicated in aging and pathogenesis of many age-related diseases including type II diabetes, atherosclerosis, and neurodegenerative disorders. Thus, pharmaceutical interventions that can reduce AGEs may delay age-onset diseases and extend lifespan. Using LC-MS(E), we show that rifampicin...

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PMID: 25720500
DOI: 10.1111/acel.12327
PMCID: PMC4406675

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PTEN

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