Article
Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy.
Science translational medicine - 25 Feb 2015
Kau Andrew L, Planer Joseph D, Liu Jie, Rao Sindhuja, Yatsunenko Tanya, Trehan Indi, Manary Mark J, Liu Ta-Chiang, Stappenbeck Thaddeus S, Maleta Kenneth M, Ashorn Per, Dewey Kathryn G, Houpt Eric R, Hsieh Chyi-Song, Gordon Jeffrey I
Abstract excerpt
To gain insights into the interrelationships among childhood undernutrition, the gut microbiota, and gut mucosal immune/barrier function, we purified bacterial strains targeted by immunoglobulin A (IgA) from the fecal microbiota of two cohorts of Malawian infants and children. IgA responses to several bacterial taxa, including Enterobacteriaceae, correlated with anthropometric measurements of nutritional status...
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