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Article

VDR gene polymorphisms impact on anemia at 2 weeks of anti-HCV therapy: a possible mechanism for early RBV-induced anemia.

Pharmacogenetics and genomics - 1 Apr 2015

Cusato Jessica, Allegra Sarah, Boglione Lucio, De Nicolò Amedeo, Cariti Giuseppe, Di Perri Giovanni, D'Avolio Antonio

Abstract excerpt

OBJECTIVES: Vitamin D receptors (VDR) bind calcitriol and modulate several physiological systems through genomic and nongenomic pathways. Calcitriol stimulates store-operated channels Ca²⁺ influx by translocation of the caveolar VDR to the plasma membrane. Intracellular Ca²⁺ levels in erythrocytes control biophysical properties and an increase in its concentration can deregulate membrane composition, cell volume,...

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Topics

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Share to 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Share to Anemia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis C

Share to Interferon-alpha

Share to Pyrophosphatases

Share to Receptors, Calcitriol

Share to Ribavirin

Share to Vitamin D3 24-Hydroxylase

Source

Identifiers

PMID: 25713999
DOI: 10.1097/FPC.0000000000000123

Genes

VDR
ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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VDR gene polymorphisms impact on anemia at 2 weeks of anti-HCV therapy: a possible mechanism for early RBV-induced anemia.PMID 25713999Read ↗

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