Article
Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment.
Molecular biology and evolution - 1 Jun 2015
Zeldovich Konstantin B, Liu Ping, Renzette Nicholas, Foll Matthieu, Pham Serena T, Venev Sergey V, Gallagher Glen R, Bolon Daniel N, Kurt-Jones Evelyn A, Jensen Jeffrey D, Caffrey Daniel R, Schiffer Celia A, Kowalik Timothy F, Wang Jennifer P, Finberg Robert W
Abstract excerpt
Influenza A virus (IAV) has a segmented genome that allows for the exchange of genome segments between different strains. This reassortment accelerates evolution by breaking linkage, helping IAV cross species barriers to potentially create highly virulent strains. Challenges associated with monitoring the process of reassortment in molecular detail have limited our understanding of its evolutionary implications....
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