Article
Rest mutant zebrafish swim erratically and display atypical spatial preferences.
Behavioural brain research - 1 May 2015
Moravec Cara E, Li Edward, Maaswinkel Hans, Kritzer Mary F, Weng Wei, Sirotkin Howard I
Abstract excerpt
The Rest/Nrsf transcriptional repressor modulates expression of a large set of neural specific genes. Many of these target genes have well characterized roles in nervous system processes including development, plasticity and synaptogenesis. However, the impact of Rest-mediated transcriptional regulation on behavior has been understudied due in part to the embryonic lethality of the mouse knockout. To investigate...
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