Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait.

doi:10.1038/ejhg.2015.3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait.

European journal of human genetics : EJHG - 1 Oct 2015

Franić Sanja, Groen-Blokhuis Maria M, Dolan Conor V, Kattenberg Mathijs V, Pool René, Xiao Xiangjun, Scheet Paul A, Ehli Erik A, Davies Gareth E, van der Sluis Sophie, Abdellaoui Abdel, Hansell Narelle K, Martin Nicholas G, Hudziak James J, van Beijsterveldt Catherina E M, Swagerman Suzanne C, Hulshoff Pol Hilleke E, de Geus Eco J C, Bartels Meike, Ropers H Hilger, Hottenga Jouke-Jan, Boomsma Dorret I

Abstract excerpt

Multiple inquiries into the genetic etiology of human traits indicated an overlap between genes underlying monogenic disorders (eg, skeletal growth defects) and those affecting continuous variability of related quantitative traits (eg, height). Extending the idea of a shared genetic basis between a Mendelian disorder and a classic polygenic trait, we performed an association study to examine the effect of 43...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Genome, Human

Share to Infant

Share to Intelligence

Share to Multifactorial Inheritance

Share to Quantitative Trait, Heritable

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 25712083
DOI: 10.1038/ejhg.2015.3
PMCID: PMC4592100

Genes

ELP2
RGS7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait.PMID 25712083Read ↗

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence.Semantic proximity Read ↗

Common genetic variants explain the majority of the correlation between height and intelligence: the generation Scotland study.Semantic proximity Read ↗

Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.Semantic proximity Read ↗

The new genetics of intelligence.Semantic proximity Read ↗

Genetic foundations of human intelligence.Semantic proximity Read ↗

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.Semantic proximity Read ↗

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligenceSemantic proximity Read ↗

Genetics and intelligence differences: five special findings.Semantic proximity Read ↗

The Genetics of Intelligence.Semantic proximity Read ↗

Genome-wide association studies establish that human intelligence is highly heritable and polygenic.Semantic proximity Read ↗

A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.Semantic proximity Read ↗

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.