Article
Active ribosomal genes, translational homeostasis and oxidative stress in the pathogenesis of schizophrenia and autism.
Psychiatric genetics - 1 Apr 2015
Porokhovnik Lev N, Passekov Vladimir P, Gorbachevskaya Nataliya L, Sorokin Alexander B, Veiko Nataliya N, Lyapunova Nataliya A
Abstract excerpt
BACKGROUND: Infantile autism and schizophrenia are severe multifactorial disorders with a pronounced genetic predisposition. Their pathogeneses are often associated with oxidative stress in the brain. Previously, we established that a cell's resistance to oxidative stress depended on the copy number of transcriptionally active genes for rRNA (ribosomal genes) in the cell's genome. The feature is measured...
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