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Article

Mycobacterial genes essential for the pathogen's survival in the host.

Immunological reviews - 1 Mar 2015

Ehrt Sabine, Rhee Kyu, Schnappinger Dirk

Abstract excerpt

Mycobacterium tuberculosis (Mtb) has evolved within the human immune system as both host and reservoir. The study of genes required for its growth and persistence in vivo thus offers linked insights into its pathogenicity and host immunity. Studies of Mtb mutants have implicated metabolic adaptation (consisting of carbon, nitrogen, vitamin, and cofactor metabolism), intrabacterial pH homeostasis, and defense...

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Identifiers

PMID: 25703569
DOI: 10.1111/imr.12256
PMCID: PMC4339221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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