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Article

OVCAR-3 spheroid-derived cells display distinct metabolic profiles.

PloS one - 1 Jan 2015

Vermeersch Kathleen A, Wang Lijuan, Mezencev Roman, McDonald John F, Styczynski Mark P

Abstract excerpt

INTRODUCTION: Recently, multicellular spheroids were isolated from a well-established epithelial ovarian cancer cell line, OVCAR-3, and were propagated in vitro. These spheroid-derived cells displayed numerous hallmarks of cancer stem cells, which are chemo- and radioresistant cells thought to be a significant cause of cancer recurrence and resultant mortality. Gene set enrichment analysis of expression data from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25688563
DOI: 10.1371/journal.pone.0118262
PMCID: PMC4331360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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