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Article

Genetic association between methylenetetrahydrofolate reductase gene polymorphism and risk of osteonecrosis of the femoral head.

BioMed research international - 1 Jan 2015

Chai Wei, Zhang Zhendong, Ni Ming, Geng Peiliang, Lian Zijian, Zhang Guoqiang, Shi Lewis L, Chen Jiying

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) SNP rs1801133 has been frequently investigated in recent years. Relevant candidate gene association studies with this SNP and osteonecrosis of the femoral head (ONFH) reported conflicting results. Meta-analysis provides a method to combine these data and to determine the association in a larger sample size. METHOD: We conducted a systematic search to...

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Identifiers

PMID: 25688352
DOI: 10.1155/2015/196495
PMCID: PMC4321101

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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