Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional variant in miR-605 modifies the age of onset in Li-Fraumeni syndrome.

Cancer genetics - 1 Jan 2000

Id Said Badr, Malkin David

Abstract excerpt

Li-Fraumeni syndrome (LFS) is a rare cancer predisposition syndrome, typically associated with germline mutations in the TP53 gene. Despite the high penetrance of TP53 mutations, LFS patients display striking phenotypic differences, suggesting the presence of secondary risk loci. To date, all genetic modifiers in LFS have been shown to map to either TP53 or its principal negative regulator, MDM2. Given this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Cell Movement
Share to Family Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Li-Fraumeni Syndrome

Share to MicroRNAs

Share to Proto-Oncogene Proteins c-mdm2

Share to Rhabdomyosarcoma

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 25683625
DOI: 10.1016/j.cancergen.2014.12.003

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional variant in miR-605 modifies the age of onset in Li-Fraumeni syndrome.PMID 25683625Read ↗

MIR605 rs2043556 is associated with the occurrence of multiple primary tumors in TP53 p.(Arg337His) mutation carriers.Semantic proximity Read ↗

Younger age of cancer initiation is associated with shorter telomere length in Li-Fraumeni syndrome.Semantic proximity Read ↗

TP53 germline mutations in Portugal and genetic modifiers of age at cancer onset.Semantic proximity Read ↗

Heterogeneity of Li-Fraumeni Syndrome links to unequal gain-of-function effects of p53 mutationsSemantic proximity Read ↗

Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome.Semantic proximity Read ↗

Functional pri-miR-34b/c rs4938723 and KRAS 3'UTR rs61764370 SNPs: Novel phenotype modifiers in Li-Fraumeni Syndrome?Semantic proximity Read ↗

p53 signaling pathway polymorphisms, cancer risk and tumor phenotype in TP53 R337H mutation carriers.Semantic proximity Read ↗

The MDM2 285G-309G haplotype is associated with an earlier age of tumour onset in patients with Li-Fraumeni syndrome.Semantic proximity Read ↗

Rare germline variant (rs78378222) in the TP53 3' UTR: Evidence for a new mechanism of cancer predisposition in Li-Fraumeni syndrome.Semantic proximity Read ↗

The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes.Semantic proximity Read ↗

A case of late-onset Li-Fraumeni-like syndrome with unilateral breast cancer.Semantic proximity Read ↗

TP53 PIN3 and MDM2 SNP309 polymorphisms as genetic modifiers in the Li-Fraumeni syndrome: impact on age at first diagnosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.