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Article

MIR605 rs2043556 is associated with the occurrence of multiple primary tumors in TP53 p.(Arg337His) mutation carriers.

Cancer genetics - 1 Jan 2020

Bandeira Isabel Cristina, Vieira Igor Araujo, Andreis Tiago Finger, Brussa Reis Larissa, Macedo Gabriel S, Vianna Fernanda Sales Luiz, Santos-Silva Patricia, Palmero Edenir Inez, Galvão Henrique de Campos Reis, Ramos Cintia Regina Niederauer, Santiago Karina Miranda, Achatz Maria Isabel, da Costa Alexandre André Balieiro Anastácio, Ashton-Prolla Patricia

Abstract excerpt

Li-Fraumeni and Li-Fraumeni-like (LFS/LFL) Syndrome are cancer predisposition syndromes caused by germline pathogenic variants in TP53 and are associated with an increased risk of multiple early-onset cancers. In Southern and Southeastern Brazil, a germline founder variant with partial penetrance located in the oligomerization domain of TP53, c.1010G>A p.(Arg337His, commonly known as R337H), has been detected in...

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PMID: 31778928
DOI: 10.1016/j.cancergen.2019.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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