Pretreatment HIV Drug Resistance and HIV-1 Subtype C Are Independently Associated With Virologic Failure: Results From the Multinational PEARLS (ACTG A5175) Clinical Trial.

doi:10.1093/cid/civ102

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Pretreatment HIV Drug Resistance and HIV-1 Subtype C Are Independently Associated With Virologic Failure: Results From the Multinational PEARLS (ACTG A5175) Clinical Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 May 2015

Kantor Rami, Smeaton Laura, Vardhanabhuti Saran, Hudelson Sarah E, Wallis Carol L, Tripathy Srikanth, Morgado Mariza G, Saravanan Shanmugham, Balakrishnan Pachamuthu, Reitsma Marissa, Hart Stephen, Mellors John W, Halvas Elias, Grinsztejn Beatriz, Hosseinipour Mina C, Kumwenda Johnstone, La Rosa Alberto, Lalloo Umesh G, Lama Javier R, Rassool Mohammed, Santos Breno R, Supparatpinyo Khuanchai, Hakim James, Flanigan Timothy, Kumarasamy Nagalingeswaran, Campbell Thomas B, Eshleman Susan H

Abstract excerpt

BACKGROUND: Evaluation of pretreatment HIV genotyping is needed globally to guide treatment programs. We examined the association of pretreatment (baseline) drug resistance and subtype with virologic failure in a multinational, randomized clinical trial that evaluated 3 antiretroviral treatment (ART) regimens and included resource-limited setting sites. METHODS: Pol genotyping was performed in a nested...

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PMID: 25681380
DOI: 10.1093/cid/civ102
PMCID: PMC4425827

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