Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour.

Human molecular genetics - 15 May 2015

Calvete Oriol, Reyes Jose, Zuñiga Sheila, Paumard-Hernández Beatriz, Fernández Victoria, Bujanda Luís, Rodriguez-Pinilla María S, Palacios Jose, Heine-Suñer Damian, Banka Siddharth, Newman William G, Cañamero Marta, Pritchard D Mark, Benítez Javier

Abstract excerpt

Gastric neuroendocrine tumours (NETs) arise from enterochromaffin-like cells, which are located in oxyntic glands within the stomach. Type I tumours represent 70-80% of gastric NETs and are associated with hypergastrinaemia, chronic atrophic gastritis and achlorhydria. Gastrin is involved in the endocrine regulation of gastric acid production. Most type I gastric NETs are sporadic, have a good prognosis and their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Exome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Neuroendocrine Tumors

Share to Pedigree

Share to Sequence Analysis, DNA

Share to Stomach Neoplasms

Share to Young Adult

Source

Identifiers

PMID: 25678551
DOI: 10.1093/hmg/ddv054

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour.PMID 25678551Read ↗

A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.Semantic proximity Read ↗

ECL‐cell carcinoids and carcinoma in patients homozygous for an inactivating mutation in the gastric H<sup>+</sup>K<sup>+</sup>ATPase alpha subunitSemantic proximity Read ↗

Whole exome sequencing of pediatric gastric adenocarcinoma reveals an atypical presentation of Li-Fraumeni syndrome.Semantic proximity Read ↗

Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid–Base Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel Mechanism for a Co-Occurring Polyautoimmune ScenarioSemantic proximity Read ↗

A cumulative effect involving malfunction of the PTH1R and ATP4A genes explains a familial gastric neuroendocrine tumor with hypothyroidism and arthritis.Semantic proximity Read ↗

Diagnosis and Management of Hereditary Carcinoids.Semantic proximity Read ↗

A MUTYH germline mutation is associated with small intestinal neuroendocrine tumorsSemantic proximity Read ↗

Somatic mutation of CDKN1B in small intestine neuroendocrine tumors.Semantic proximity Read ↗

Hereditary neuroendocrine tumors of the gastroenteropancreatic system.Semantic proximity Read ↗

Pathophysiology of Gastric NETs: Role of Gastrin and Menin.Semantic proximity Read ↗

Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors.Semantic proximity Read ↗

Tumor suppressor ATP4B serve as a promising biomarker for worsening of gastric atrophy and poor differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.