Article
Hereditary neuroendocrine tumors of the gastroenteropancreatic system.
Virchows Archiv : an international journal of pathology - 1 Aug 2007
Anlauf Martin, Garbrecht Nele, Bauersfeld Juliane, Schmitt Anja, Henopp Tobias, Komminoth Paul, Heitz Philipp U, Perren Aurel, Klöppel Günter
Abstract excerpt
Approximately 5-10% of neuroendocrine tumors (NETs) of the gastroenteropancreatic system (GEP) have a hereditary background. The known inherited syndromes include multiple endocrine neoplasia type 1, neurofibromatosis type 1, von Hippel-Lindau disease, and the tuberous sclerosis complex. This review discusses for each of these syndromes the: (1) involved genes and specific types of mutations, (2) disease...
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