Article
Rett syndrome.
Child and adolescent psychiatric clinics of North America - 1 Jul 2007
Ben Zeev Ghidoni Bruria
Abstract excerpt
Rett syndrome (RS) is an X-linked neurodevelopmental disorder and the second most common cause of genetic mental retardation in females. Different mutations in MECP2 are found in up to 95% of typical cases of RS. This mainly neuronal expressed gene functions as a major transcription repressor. Extensive studies on girls who have RS and mouse models are aimed at finding main gene targets for MeCP2 protein and...
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