Article
Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss.
Nature genetics - 1 Mar 2015
Xu Heng, Robinson Giles W, Huang Jie, Lim Joshua Yew-Suang, Zhang Hui, Bass Johnnie K, Broniscer Alberto, Chintagumpala Murali, Bartels Ute, Gururangan Sri, Hassall Tim, Fisher Michael, Cohn Richard, Yamashita Tetsuji, Teitz Tal, Zuo Jian, Onar-Thomas Arzu, Gajjar Amar, Stewart Clinton F, Yang Jun J
Abstract excerpt
Taking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P = 3.9 × 10(-8), hazard ratio = 4.5) in 238 children with newly diagnosed brain tumors, with independent replication in 68 similarly treated children. The ACYP2 risk variant strongly predisposed these patients to precipitous hearing loss and was related to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.