Article
Analysis of major genome loci underlying artemisinin resistance and pfmdr1 copy number in pre- and post-ACTs in western Kenya.
Scientific reports - 6 Feb 2015
Ngalah Bidii S, Ingasia Luiser A, Cheruiyot Agnes C, Chebon Lorna J, Juma Dennis W, Muiruri Peninah, Onyango Irene, Ogony Jack, Yeda Redemptah A, Cheruiyot Jelagat, Mbuba Emmanuel, Mwangoka Grace, Achieng Angela O, Ng'ang'a Zipporah, Andagalu Ben, Akala Hoseah M, Kamau Edwin
Abstract excerpt
Genetic analysis of molecular markers is critical in tracking the emergence and/or spread of artemisinin resistant parasites. Clinical isolates collected in western Kenya pre- and post- introduction of artemisinin combination therapies (ACTs) were genotyped at SNP positions in regions of strong selection signatures on chromosome 13 and 14, as described in Southeast Asia (SEA). Twenty five SNPs were genotyped...
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