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Article

Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study

11 May 2011

Abstract excerpt

INTRODUCTION: Cross-talk between the coagulation system and inflammatory reactions during sepsis causes organ damage followed by multiple organ dysfunction syndrome or even death. Therefore, anticoagulant therapies have been expected to be beneficial in the treatment of severe sepsis. Recombinant human soluble thrombomodulin (rhTM) binds to thrombin to inactivate coagulation, and the thrombin-rhTM complex...

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PMID: 21569368
DOI: 10.1186/cc10228

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