A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study.

doi:10.1007/s10689-015-9813-0

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A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study.

Familial cancer - 1 Dec 2015

Bayram Süleyman, Ülger Yakup, Sümbül Ahmet Taner, Kaya Berrin Yalınbaş, Rencüzoğulları Ahmet, Genç Ahmet, Sevgiler Yusuf, Bozkurt Onur, Rencüzoğulları Eyyüp

Abstract excerpt

An aberrant up-regulation of HOX transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is associated with human cancers including gastric cancer (GC) and worse clinicopathological features. A naturally occurring functional single nucleotide polymorphism (SNP) rs920,778 (C→T) in the intronic enhancer of HOTAIR gene has been demonstrated to affect HOTAIR expression and cancer susceptibility....

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PMID: 25980897
DOI: 10.1007/s10689-015-9813-0

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