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Article

The noncoding human genome and the future of personalised medicine.

Expert reviews in molecular medicine - 30 Jan 2015

Cowie Philip, Hay Elizabeth A, MacKenzie Alasdair

Abstract excerpt

Non-coding cis-regulatory sequences act as the 'eyes' of the genome and their role is to perceive, organise and relay cellular communication information to RNA polymerase II at gene promoters. The evolution of these sequences, that include enhancers, silencers, insulators and promoters, has progressed in multicellular organisms to the extent that cis-regulatory sequences make up as much as 10% of the human...

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PMID: 25634368
DOI: 10.1017/erm.2014.23

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