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Asparaginyl endopeptidase cleaves TDP‐43 in brain

21 Jun 2012

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) is a nuclear protein involved in RNA splicing and a major protein component in ubiquitin-positive, tau-negative inclusions of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Under disease conditions, TDP-43 redistributes to the cytoplasm where it can be phosphorylated, ubiquitinated, and proteolytically cleaved. Enzymes responsible for TDP-43 proteolytic...

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PMID: 22718532
DOI: 10.1002/pmic.201200006

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