Article
Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood.
European journal of human genetics : EJHG - 1 Oct 2015
Mastrokolias Anastasios, Ariyurek Yavuz, Goeman Jelle J, van Duijn Erik, Roos Raymund A C, van der Mast Roos C, van Ommen GertJan B, den Dunnen Johan T, 't Hoen Peter A C, van Roon-Mom Willeke M C
Abstract excerpt
With several therapeutic approaches in development for Huntington's disease, there is a need for easily accessible biomarkers to monitor disease progression and therapy response. We performed next-generation sequencing-based transcriptome analysis of total RNA from peripheral blood of 91 mutation carriers (27 presymptomatic and, 64 symptomatic) and 33 controls. Transcriptome analysis by DeepSAGE identified 167...
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